EFFECT OF SWARNA SINDURA ON THYROID HORMONES IN SPRAGUEDAWLEY RATS

Md. Afaz Uddin1, Md. Rakib Hasan1*, Arjyabrata Sarker1, Uday Krishna Mondal1, Sagor Chandra Roy1, Md. Al Foyjul Islam1, Marjana Khalil2, M. S. K. Choudhuri1.

Swarna Sindura (SS) is an ayurvedic preparation used as a traditional medicine in the treatment of neurasthenia. In this study, effect of SS on thyroid hormone profile was evaluated after chronic administration of this drug to male Sprague-Dawley rats. The acute pharmacological test of SS recorded no death or any signs of toxicity even at the highest dose of 4000 mg/Kg body weight. For chronic pharmacological evaluation, the animals were divided into two groups. The first group was given SS preparation at a dose of 40 mg/kg body weight for 28 days while the second group that served as the control received water for the same period. After 28 days of chronic administration of the SS preparation the following effects on the thyroid hormone profile were noted. There was a statistically highly significant (p=0.008, 15.62 % increase) increase in the serum circulating free Triiodothyronine (fT3) level. The drug (SS) did not affect serum circulating total Thyroxine (tT4) level, total Triiodothyronine (tT3) level, free Thyroxine (fT4) level and Thyroid stimulating hormone (TSH) significantly.