GET THE APP

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

EFFECT OF COMPETITIVE BINDING OF HYPOGLYCEMIC AGENTS TO HUMAN SERUM ALBUMIN ON DRUG PHARMACOLOGY

Neelam Seedher* and Mamta Kanojia

For the highly protein-bound anti-diabetic drugs with a small volume of distribution, competitive binding to human serum albumin can significantly influence the pharmacological activity of drugs resulting in serious fluctuations in the blood glucose levels of diabetic patients. In this paper, competitive binding studies using fluorescence spectroscopic technique have been reported for a wide range of drug combinations involving oral hypoglycemic (anti-diabetic) agents. For the drug combinations used, such studies are not available in the literature. The results indicated that the combination of gliclazide and repaglinide with the studied competing drugs can increase the risk of hypoglycemia in diabetic patients and should be avoided. On the other hand, the corresponding combinations involving glimepiride and glipizide were found safe. The therapeutic efficacy of studied competing drugs, on the other hand decreased in the presence of antidiabetic drugs in most cases. Competitive binding mechanism based on the site-specificity and conformational changes in the human serum albumin molecule has been proposed.


PDF
scan code pharma scholars

Manuscript Submission

Submit your manuscript at  Online Submission System


Google scholar citation report
Citations : 1101

International Journal of Pharmacy received 1101 citations as per google scholar report

International Journal of Pharmacy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • HINARI
  • Index Copernicus
  • Google Scholar
  • The Global Impact Factor (GIF)
  • Polish Scholarly Bibliography (PBN)
  • Cosmos IF
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • EBSCO A-Z
  • OCLC- WorldCat
  • MIAR
  • International committee of medical journals editors (ICMJE)
  • Scientific Indexing Services (SIS)
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Eurasian Scientific Journal Index
  • Root indexing
  • International Institute of Organized Research
  • InfoBase Index
  • International Innovative Journal Impact Factor
  • J-Gate