GET THE APP

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

DEVELOPMENT OF LIQUID CHROMATOGRAPHIC AND VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF CLOBAZAM IN TABLET DOSAGE FORMS

K. Uma Maheshwar, Golkonda Ramu, Chintala Rambabu*

An isocratic RP-HPLC method (Method-A) and two visible spectrophotometric methods (Method B and C) were developed and validated for the determination of Clobazam in bulk and tablet dosage forms. In Method-A, a PEAK chromatographic system equipped with Zodiac C-18 (250mm, 4.6mm and 5μm) column, mobile phase of composition 10:30:60 (v/v/v) of tetra hydro furan (THF), methanol (MeOH) and acetonitrile (ACN), UV detector were adopted for the chromatographic analysis. The output signal was monitored at a detection wavelength at 227 nm and integrated by PEAK Chromatographic Software version 1.06. In spectrophotometric methods, the chromogenic reagents such as Fe (II)-1, 10 phenanthroline (Methods-B) and ferricyanide-Fe (III) (Method-C) reagents were used for color development for the estimation of Clobazam in pure and formulations. The developed methods were validated according ICH guidelines and adopted for the assay of clobazam in the bulk drug and formulations.


PDF

Manuscript Submission

Submit your manuscript at  https://www.scholarscentral.org/submissions/international-pharmacy.html


Google scholar citation report
Citations : 938

International Journal of Pharmacy received 938 citations as per google scholar report

International Journal of Pharmacy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • HINARI
  • Google Scholar
  • The Global Impact Factor (GIF)
  • Polish Scholarly Bibliography (PBN)
  • Cosmos IF
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • EBSCO A-Z
  • International committee of medical journals editors (ICMJE)
  • Scientific Indexing Services (SIS)
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Eurasian Scientific Journal Index
  • Root indexing
  • International Institute of Organized Research
  • InfoBase Index
  • International Innovative Journal Impact Factor