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Abstract

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF OLMESARTAN MEDOXOMIL AND METOPROLOL SUCCINATE IN PHARMACEUTICAL PREPARATIONS

Sohan S. Chitlange, Reshma A. Talole, Ramesh D. Bhusal and Monesh B. Nikumbh

Simple, accurate, and reproducible two UV-spectrophotometric methods have been developed for simultaneous estimation of Olmesartan Medoxomil (OLME) and Metoprolol Succinate (METO) in tablet dosage form. The first UV- Spectrophotometric method was a determination using the Area Under Curve method and the second UV method was a determination using the Multi-Component mode method at 256.5 nm and 222.0 nm over the concentration range 5-30 μg/mL and 5-30 μg/mL for OLME and METO respectively. Both UV-spectrophotometric methods were statistically validated and can be used for analysis of combined dose tablet formulation containing OLME and METO.


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