DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN PURE BULK AND PHARMACEUTICAL DOSAGE FORM

D. Sreelatha, R. Ramya and T. Ramarao

A simple, Accurate, precise method was developed for the simultaneous estimation of the Nebivolol and Valsartan in Tablet dosage form. Retention time of Nebivolol and Valsartan were found to be 2.496min and 3.905min. %RSD of the Nebivolol and Valsartan were and found to be 0.4 and 0.8 respectively. %Recover was Obtained as 99.52% and 99.93% for Nebivolol and Valsartan respectively. LOD, LOQ values are obtained from regression equations of Nebivolol and Valsartan were 0.070ppm, 0.2142ppm and 0.179ppm, 0.544 ppm respectively. Regression equation of Nebivolol is y = = 0722x + 144.0, and y = 4560x + 248.2 of Valsartan . Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.