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Abstract

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METOPROLOL SUCCINATE AND CILNIDIPINE IN COMBINED TABLET DOSAGE FORM

Pavan Kumar.V*, G. Lokeswara, Dr. V.Haribaskar, Dr. M.Gobinath

A simple, accurate and precise method was developed for the simultaneous estimation of Metoprolol and Cilnidipine in Tablet dosage form. Chromatogram was run through Altima (150 x 4.6 mm, 5m). Mobile phase containing Buffer (0.1%OPA) and Methanol in the ratio of 45:55 v/v was pumped through column at rate of 1ml/min. Temperature was maintained at 30°C. Optimized wavelength for Metoprolol and Cilnidipine was 225nm. Retention time of Metoprolol and Cilnidipine was found to be 2.249min and 3.062 min. %Assay was obtained as 101.22% and 100.45% for Metoprolol and Cilnidipine respectively. The accuracy and reliability of the method was assessed by evaluation of linearity, precision (intra-day and inter-day % RSD >2), accuracy and specificity for Metoprolol and Cilnidipine in accordance with ICH guidelines.


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