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Abstract

DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR ESTIMATION OF LEVOCETIRIZINE AND MONTELUKAST IN PHARMACEUTICAL DOSAGE FORM

Ch. Harika, Gajja Vijaykumar and Kudipudi Harinadhbabu

A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination levocetirizine and montelukast in pharmaceutical dosage form. The column used was Thermosil C18 (150×4.6 mm, 3.5μm) in isocratic mode, with mobile phase containing phosphate buffer-acetonitrile (30:70) adjusted to pH 3.6 using ortho phosphoric acid was used. The flow rate was 1.0 mL/ min and effluents were monitored at 232 nm. The retention times of levocetirizine and montelukast were 2.213 min and 5.674 min, respectively. The linearity for levocetirizine and montelukast were in the range of 50-90 mg/mL and 100-140 mg/mL respectively. The recoveries of levocetirizine and montelukast were found to be 100.31% and 100.37%, respectively. The proposed method was validated and successfully applied to the estimation of levocetirizine and montelukast in combined tablet dosage forms.


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Citations : 938

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