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Abstract

DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR ESTIMATION OF LAMOTRIGINE IN A TABLET DOSAGE FORM

Dr M. Paul Richard*1, Dr Kiran Kumar1, P.Govardhan Reddy1, P.Uma Mahesh2

A simple, sensitive, and precise high performance liquid chromatographic method for the analysis of Lamotrigine has been developed and validated for the determination of compound in commercial pharmaceutical products. The compounds were well separated on BDS Hypersil C18 reverse phase column by the use of a mobile phase of mixed phosphate buffer and acetonitrile in a ratio of 40:60 v/v, at a flow rate of 1.0 ml/min with detection wavelength at 248nm. The method was validated in terms of linearity, precision, accuracy, and specificity, robustness and solution stability. The method does require only 10 minutes as runtime for analysis which prove the adoptability of the method for the routine quality control analysis of the drug. 


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Google scholar citation report
Citations : 938

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