GET THE APP

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

DEVELOPMENT AND EVALUATION OF PRESS COATED TABLET BY USING RUPTURABLE MATERIAL (EC) COMBINED WITH ERODIBLE MATERIAL (KLUCEL EXF) OF ACECLOFENAC

Mayee RV and Shinde PV

The objective of this study was to develop and evaluate a press-coated pulsatile drug delivery system intended for treatment of early morning stiffness and symptomatic relief from pain in patients with rheumatoid arthritis with a distinct predetermined lag time of 6 h .Aceclofenac as a model drug by using various proportion of polymers such as rupturable material (EC) combined with erodible material (klucel EXF). Seven formulations were prepared and formulation F2 possessed good lag time time 6 hr and showed pulsatile drug delivery pattern the tablets were also evaluated for its hardness, friability and other In- vitro evaluation tests. All parameters complied with IP limits. Results of this study indicated that the combinations of rupturable material (EC) combined with erodible material (klucel EXF) are suitable to optimize pulsatile drug release formulation of aceclofenac. The formulation involved press coating of a rupturable coat around a rapidly disintegrating core tablet of aceclofenac.


PDF

Manuscript Submission

Submit your manuscript at  https://www.scholarscentral.org/submissions/international-pharmacy.html


Google scholar citation report
Citations : 938

International Journal of Pharmacy received 938 citations as per google scholar report

International Journal of Pharmacy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • HINARI
  • Google Scholar
  • The Global Impact Factor (GIF)
  • Polish Scholarly Bibliography (PBN)
  • Cosmos IF
  • Open Academic Journals Index (OAJI)
  • Directory of Research Journal Indexing (DRJI)
  • EBSCO A-Z
  • International committee of medical journals editors (ICMJE)
  • Scientific Indexing Services (SIS)
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Eurasian Scientific Journal Index
  • Root indexing
  • International Institute of Organized Research
  • InfoBase Index
  • International Innovative Journal Impact Factor