DEVELOPMENT AND EVALUATION OF MICROSPONGE DRUG DELIVERY SYSTEM OF INDOMETHACIN

Inukonda Rajitha*, Dr K. Umasankar, Dr. P. Jayachandra reddy

In the present study controlled release formulation of Indomethacin microsponges were prepared by using Carbopol
940, PVA. Microsponges were prepared by Quasi emulsion solvent diffusion method by changing drug polymer
ratio (1:0.5-1:4) and process was optimized. Microsponges were evaluated by micromeritic properties, drug content,
encapsulation efficiency, and particle size. Characterization of Indomethacin microsponges were done by FT-IR
spectroscopy,. In-vitro dissolution study indicated that the release of Indomethacin varied according to the
concentration of matrix forming polymer, drug release mechanism was found to be super case II transport
Therefore, Indomethacin microsponges prepared in thus study are promising as being more useful than conventional
formulation intherapy.