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Abstract

DESIGN OF OCULAR CONTROLLED RELEASE OCUSERTS OF BRINZOLAMIDE

Snehaprabha Lad*, Amrita Bajaj

The objective of research was to formulate and evaluate controlled release drug delivery system like ocuserts of Brinzolamide, an anti-glaucoma agent. Ocuserts were formulated using various polymers and plasticizers by film casting technique as drug reservoir membrane and controlled release polymers like Eudragit as the rate limiting membrane. The ocuserts were evaluated for physical characteristics, pH, uniformity in thickness & weight, swelling index, folding endurance, percent moisture loss, uniformity of drug content, in vitro diffusion studies. The ocusert containing HPMC K4M, HPMC E50 (1:1), Eudragit E100 showed controlled release with 82.00% ± 0.594 at the end of 24 hours. Ex-vivo study showed 80.00 ± 1.003% of drug permeation. SEM analysis showed drug was in crystal form in the matrix of Ocusert, the surface had pores. IR and DSC studies confirmed no drug-polymer interaction. The optimized formula was sterilized and subjected to stability studies. No ocular irritation was seen in ocular irritancy study.


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