Manjunath Setty M1, Surendra Swarnkar1, Neha Laxane2, Sumit Laxane1*
In this study, various transdermal matrix patches containing Commiphora mukul of variable combination of ethyl cellulose/polyethylene glycol with enhancer (menthol: limonene) were prepared. The prepared patches were studied with respect to physicochemical characters, drug-excipient interaction, dissolution, skin permeation, stability and in vivo anti-inflammatory studies. The combination of ethyl cellulose and polyethylene glycol produces smooth flexible films. Dissolution and in vitro skin permeation studies revealed that the cumulative amount of drug permeated was decreased as the polyethylene content of the film increased. The film containing enhancer shows greater release as compared to film containing no enhancer. Based on in vitro skin permeation studies, CM4 [PEG/EC, 1:5, menthol (36 ug): limonene (36 ul)], was found to be better formulation as it released a maximum amount of drug. In stability studies, all the formulations were stable with respect to physical properties up to 45 days.
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