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Abstract

COMPLEXATION, OPTIMIZATION, FORMULATION DEVELOPMENT AND CHARACTERIZATION OF CLINDAMYCIN PHOSPHATE GEL USING ZINC ACETATE DIHYDRATE

Manoj Kumar Mishra and Pramod Kumar Biswal

A stable zinc-clindamycin complex gel was formed by optimizing concentration of clindamycin phosphate (1.188gm) and zinc acetate dehydrate (500 mg), determining optimum pH condition (pH 7.5) and stabilizing (pH 5-8) the complex using various gelling agents. Drug identification was carried out by FTIR and DSC study. Related substances analysis and quantitative determination of drug were carried out on HPLC. Physical parameters like color, smoothness/ grittiness, ease of application, oiliness/greasiness, skin irritation, pH and viscosity of gel were conducted from time to time. Antimicrobial effectiveness test were screened against five selected pathogens. A Franz diffusion cells system was used to determine the release rate profile of the formulation which produces better result comparable to the marketed product (Dalacin® lotion) concludes the topical application of gel useful in acne vulgaris is capable of storage during shelf life for longer period of time without losing its therapeutic effectiveness and maintaining the uniformity.


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Citations : 938

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