COMPARATIVE PET STUDY BETWEEN TWO PROSTAGLANDIN DERIVATIVES OPHTHALMIC SOLUTIONS

Kashyap Nagariya, Piyush Sharma, Anil Bhandari, Sarangdevot YS and Chouhan CS

Although in vitro and in vivo laboratory studies have suggested that benzalkonium chloride (BKC) in ophthalmic solutions may be detrimental to corneal epithelial cells, multiple short- and long-term clinical studies have provided evidence supporting the safety of BKC. Despite the conflicting evidence, BKC is the most commonly used preservative in ophthalmic products largely due to its proven antimicrobial efficacy. This study was designed to characterize the preservative efficacy performance of two commonly used ocular hypotensive agents that employ BKC as preservative: latanoprost with 0.01% BKC and travoprost 0.02% BKC, in an isotonic buffer solution.