CHRONOMODULATION: A PLATFORM FOR FUTURE DOSAGE FORMS

Rahul Bhaskar, Radhika Bhaskar*, Mahendra K. Sagar and Vipin Saini

Gone are the days when patient incompliance was due to cumbersome dosage regimen. The mesmerizing technology of alteration in the time of release of the drug has not only opened up new possibilities but also has made many drug products based on them commercially available. These systems are based on the basic physiological phenomenon known as biological clock or circadian rhythm i.e. a daily cycle of biological activities which may get influenced with the environmental and several other factors. The system ensures the drug is released at the time of its requirement hence known as chronomodulated (chrono means ‘time’ and modulation means ‘alteration’) drug delivery systems. There are a good number of platform technologies which either can be utilized as such or can be amended a bit to get the desired product. This review article deals with such technologies along with their commercially available products.