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Biological evaluation of some new 1,3-benzothiazole-2-yl derivatives containing pyrazole moiety

Deepa Chauhan*, A. A.Siddiqui, Rajkumari Kataria, Dr. Robin Singh

A series of 2-[3-(substituted phenyl)-4-formylpyrazol-1-yl]-6-nitro benzothiazole derivatives (5a-g) have been synthesized through Vilsmeier-Haack reaction on hydrazones (4a-g) of appropriate substituted aromatic ketones with 6-nitro-benzothiazol-2-yl hydrazine under microwave irradiation in fairly good yields. Structural assignments of the synthesized compounds were based on their IR, 1HNMR, mass spectral studies and elemental analysis. Those compounds were also screened for their in vitro antibacterial against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae and antifungal activity against Aspergillus niger and Candida albicans. Some of the compounds exhibited promising antibacterial and antifungal activities as compared to reference drugs Norfloxacin and ketoconazole.

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