Dr. Reena Eknath Dudhe1, Dr. N. Vimala2, Dr. Leena Padhye3
In recent years, free radical chemistry has received a great deal of attention. Our body generates Free radicals as reactive oxygen species (ROS) and reactive nitrogen species (RNS) by various endogenous systems and exposure to various physiochemical conditions or pathological states. Oxidative stress results if free radicals overwhelm the body’s ability to regulate them. Free radical thus decreases lipids, proteins, and DNA and leads to number of human diseases. Hence use of external source of antioxidants can help to overcome this oxidative stress. Over the past years, the free radicals and antioxidants have gained tremendous importance in the era of dentistry. These free radicals in the body, can be beneficial or hazardous. Antioxidants are the substances that coincide with and stabilize free radicals thereby guarding and sheltering cells from the harm caused by free radicals. The present article represents a review how free radicals are formed, their interaction in disease pathogenesis, and their potential use in endodontics.
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