ANTIEPILEPTIC ACTIVITY OF MURRAYA KOENIGII LEAF AQUEOUS EXTRACT IN PENTYLENETETRAZOLE AND STRYCHNINE INDUCED CONVULSIONS IN RATS AND MICE

Vanna Manjusha*, Gella Suneel

The aim of present study was to investigate antiepileptic activity of aqueous extract of Murraya koenigii (AEMK) on pentylenetetrazole (PTZ) and strychnine (STR) induced convulsions in mice and rats respectively. 24 male Swiss mice and 24 male Wistar rats were divided into four groups of six animals each as I, II, III and IV which were treated with 0.9 % saline (10 ml/kg, p.o.), Diazepam (4 mg/kg, i.p.), AEMK (200 mg/kg. p.o), AEMK treated (400 mg/kg. p.o). All mice were treated with PTZ (75 mg/kg, i.p.) and all rats with Strychnine (2 mg/kg, i.p.), 30 min after i.p administration of diazepam and 60 min after oral administration of saline and extract doses. Onset and duration of convulsions, percentage protection, Severity score and mortality rate in rats and mice were recorded. Statistical analysis was carried out by ANOVA followed by Barlett’s test. In present study AEMK decreased severity of convulsions, increased percentage protection, decreased mortality rate and exhibited significant antiepileptic activity.