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Abstract

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN BULK AND PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD

B. Siddartha*, I. Sudheer Babu, Ch. Ravichandra Gupta, C. Parthiban

A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination nebivolol and valsartan in pharmaceutical dosage form. The using Altima C18 (4.6 x 150mm, 5µ) column in isocratic mode, with mobile phase containing phosphate buffer and acetonitrile (52:48 v/v) adjusted to pH 4.8 with dilute ortho phosphoric acid solution. The flow rate was 1.0 ml/ min and effluents were monitored at 282 nm. The retention times of nebivolol and valsartan were found to be 2.325 min and 5.172 min, respectively. The linearity for nebivolol and valsartan were in the range of 2.5-7.5μg/ml and 40-120μg/ml respectively. The recoveries of nebivolol and valsartan were found to be 100.04% to 101.36% and 99.86% to 101.62%, respectively. The proposed method was validated and successfully applied for the estimation of nebivolol and valsartan in combined tablet dosage forms.


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Citations : 938

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