ANALGESIC AND NEUROPHARMACOLOGICAL INVESTIGATIONS ON SESBANIA GRANDIFLORA

Mir Muhammad Nasir Uddin, Md. Ruhul Amin, Amitabh Basak, Mohammad Shahriar*

This study was designed to evaluate the analgesic and neurophramacological investigations of leaf extract of Sesbania grandiflora in Swiss albino mice following oral administration. In-vivo analgesic activity test was evaluated by acetic acid induced writhing method and tail immersion test. In-vivo neurophramacological investigations was determined by open field and hole cross test. In-vivo analgesic activity test shows that methanolic extract (250 & 500 mg/kg b.w.) performed good activity in mice comparing to the standard drug diclofenac Na. Methanolic extract of Sesbania grandiflora displayed a significant and dose dependent analgesic activity, the percent inhibition was 68.13%, 85.56% respectively in the test group (250 & 500 mg/kg b.w.).