ANALGESIC ACTIVITY OF METHANOLIC BARK EXTRACT OF VITEX NEGUNDO Linn

Sampath kumar Ch, Rajender Arutla and Sunil Kumar M

The present study was undertaken to assess the analgesic effect of methanolic extract of Vitex negundo bark in albino rats. The analgesic action in acute pain models was studied by tail flick method and hot plate method. The methanolic extract of Vitex negundo bark was screened for phytochemical analysis and it�??s revealed the presence of all components. The adult Sprague- Dawley rats were divided into four groups of six each and maintained under ideal laboratory conditions. Group I was taken as control and group II treated with the standard drug diclofenac sodium (9mg/kg), the methanolic extract of Vitex negundo bark 200mg/kg and 300mg/kg were fed to group III, IV. It is observed that the both Vitex negundo bark shows considerable analgesic effect in acute pain models which is less than the effect of Diclofenac group. The higher dose groups of Vitex negundo bark extract (300mg/kg) was revealed more activity than their corresponding lower dose.