ACUTE TOXICITY, SPECTROSCOPIC AND MOLECULAR MODELING STUDIES OF SCHIFF BASE DERIVED FROM L-METHIONINE AND 2-HYDROXY-1- NAPHTHALDEHYDE

Wasfi A. Al-Masoudi*, Mohammed A. Al-Diwan and Jalal A. Mojbal

Condensation 2-hydroxy-1-naphthaldehyde 1 with L-methionine 2 yielded E-((2)-(((2-hydroxynapthalene-1- yl)ethylene)amino)-4-(methylthio)butanoic acid 3 in a good yield. The synthesized compound was characterized by elemental analysis, IR and ¹H, ¹³C, HSQC, HMBC and ROSY NMR spectroscopy. The toxicity study of the synthesized analogue 3 was assayed for its LD₅₀ value by using Dixon,s up and down method, which exhibited value of 477 mg / kg of body weight. Molecular modeling studies were performed, showing the hydrogen bending and hydrophobic interactions.