N. Kalyani Reddy*, A. Archana, Sridhar Siddiraju
A simple, reproducible and cost effective spectroscopic method developed and validated for anagrelide in bulk and tablet dosage form. The drug was determined by using dimethyl sulfoxide and 0.1 N NaOH (1:4) as diluent at 300 nm. Validation was performed as ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The %recovery study for the proposed method is 98-108%w/v indicating no interferences of the tablet excipients. Linearity was obtained in concentration range of 2-10µg/ml for anagrelide with correlation coefficient of 0.999. The detection limit and quantitation limit was found to be 0.0419 and 0.127 respectively.
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