Anwar Khan*, Rishabha Malviya, Pramod K Sharma
Solubility is the process of dissolution of solid in liquid phase to give a homogenous system and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Dissolution rate of poorly water-soluble drugs is rate limiting step for its bioavailability so increase in bioavailability is the major challenging task in drug development. Because only 8% of new drug candidates have both high solubility and permeability. For BCS class II drugs, enhancement of Solubility and hence bioavailability is important parameter before formulation of dosage form. Hydrophobic drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules. Various techniques are used for the improvement of the aqueous solubility, dissolution rate, and bioavailability of poorly water soluble drugs include size reduction, chemical modification, pH adjustment, solid dispersion, complexation, co???solvency, hydrotropy etc. the main emphasis of review article is to describe the techniques of solubilisation for the attainment of effective absorption with improved bioavailability.
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