Mahmoud El-Shahat *, Eman A. Elhefny, Ahmed A. El-Sayed, Mowafia A.M. Salama
Because of its potent and significant pharmacological activities, The 2-amino-4,6-bis(4-chlorophenyl) nicotinonitrile (1) used as a starting material to synthesis of pyridopyrimidine derivatives 3–7. On the other hand, we used the pyridopyrimidine 4 to synthesis of tricycle heterocyclic derivatives; pyridopyrimidotriazine 8–10; pyridotriazolopyrimidine 11–13 and pyridotetrazolopyrimidine 14.
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