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Abstract

A NEW VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RAMIPRIL AND OLMESARTAN MEDOXOMIL

Deepthi Yada*, Divya Yada*, T. Rajeshwari, M. Madhavilatha, G. Tulja Rani

The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Ramipril and and Olmesartan medoxomil in tablet formulation. Chromatography was performed on a Hypersil C18 (4.6mmx250mm, 5?m) column from inisocratic mode with mobile phase containing acetonitrile: 0.05 M KH2PO4 pH 3.0 (60:40). The flow rate was 1.0 ml/min and the eluent was monitored at 228 nm. The selected chromatographic conditions were found to effectively separate Ramipril (RT- 2.836 min) and Olmesartan (RT- 4.055 min). Linearity for Ramipril and Olmesartan medoxomil were found in the range of 5ppm- 25ppm and 20ppm -100ppm respectively. The proposed method was found to be accurate, precise, reproducible and specific. The mean recovery was 99.84 ± 0.20% and 101.7 ± 0.20% for ramipril and olmesartan medoxomil respectively. The methods were validated according to the ICH guidelines.


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