IRON OVER LOAD INDUCED LIVER TOXICITY OF AQUEOUS LEAF EXTRACT OF CARICA PAPAYA IN RATS Balakrishna V, Srikanth G, Ajay kumar Sarabu, Thippani Maneshwar The leaf extract of Carica papaya have been widely used in Ayurveda to treat a variety of common disorders like neurodegenerative diseases, cardio vascular diseases, cancer. In the present investigation, the aqueous leaf extract of C.papaya was evaluated for antioxidant activity in iron over load induced liver toxicity. For the evaluation of iron over load liver toxicity method was daily treatment of C.papaya extract on the 5th day iron load was induced. The animals were sacrificed by light ether anesthesia and it was dissected .Tissue homogenate and blood samples were assess the SGOT, ALP, and LPO, Reduced glutathione, Protein & Catalase in normal and iron over load groups. The daily administration of aqueous leaf extract of C.papaya at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg body weight to iron over load liver toxicity methods were significantly reduced in a dose dependent manner. However, no change observed in the normal animals at all the doses studied. The extract also produced significant reduction of hydroxyl radicals in comparison to ascorbic acid in a dose dependent manner. The result have shown that the aqueous extract of the Leaf of Carica papaya  possesses antioxidant properties, supported by the decrease in lipid peroxidation and increase in the reduced glutathione and catalase activity in in-vivo method. Such antioxidant activity of Carica papaya might be responsible for its importance in traditional medicine for the treatment of various disorders. International Journal Of Pharmacy 2249-1848 2014-02-21 1 425-430 Copyright (c) Pharma Scholars. All rights reserved 2013