DETOXIFIED JATROPHA CURCAS KERNEL MEAL IMPACT AGAINST BENZENE-INDUCED GENETIC TOXICITY IN MALE RATS Sabah A. A. Linjawi, Wagdy K. B. Khalil, Lamia M. Salem Pollution by crude oil is wide spread and a common problem, and particularly endemic in countries whose economies are dependent on the oil industry. Such pollution arises either accidentally or operationally wherever oil is produced, transported, stored, processed or used. Benzene contamination of soil may also occur due to oil production facilities and coastal refineries. This problem arises because most of petrochemicals including benzene and its derivatives are carcinogens and mutagens with the capacity to affect both the structural integrity of DNA and the fidelity of its biologic expression. Jatropha curcas (L.) is a multipurpose and drought resistant tree, widespread throughout the tropics and subtropics. Its seeds are rich in oil and protein. J. curcas can also be used for human food, animal feed, fertilizer, fuel and traditional medicine. Therefore, the objective of this work is to evaluate protective effect of detoxified J. curcas kernel meal (DJKM) against benzene-induced clastogenicity in male rats. Eighty adult male rats were allocated in several groups treated with benzene and/or several concentration of DJKM. The results revealed that low, medium and high doses of DJKM did not increase the DNA fragmentation, incidence of MnPCEs and alterations in the stress related genes (Hsp70a, MT and CYP450 genes) compared with benzene induced high levels of these parameters. The protection effects of DJKM on the genetic toxicity were attributed to its imact on the glutathione peroxidase activity which was increased significantly with DJKM treatment compared to benzene exposure. International Journal Of Pharmacy 2249-1848 2014-10-02 4 57-66 Copyright (c) Pharma Scholars. All rights reserved 2013