FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILMS OF ZOLPIDEM TARTRATE BY EXPLORATION OF POLYMERS COMBINATION *M.K. Patidar, F.A. Karjikar, F.A. Patel, S.S. Rathi, S.B. Thokal, C.L. Bhingare Fast dissolving drug delivery is the new approach to administer drugs; mouth dissolving film is one of them. The object of the present research work was to formulate a mouth dissolving film of Zolpidem tartrate from polymers Hydroxypropyl cellulose (EF-P) with a combination of Hydroxypropyl methyl cellulose K-15 by solvent casting method for enhancing the drug release rate and absorption to incessant increase drug bioavailability. Hydroxypropyl cellulose is a synthetic water soluble polymer, form a brittle film with high elastic modulus, thus to improve film forming properties, Hydroxypropyl methyl cellulose used in a ration of (1:1 and 2:1) with it. Compatibility of drug and polymers were studied by the IR spectrophotometer, any kind of interaction was not found. All the formulations were evaluated by different evaluation parameters and showed satisfactory results. Batches have uniformity in weight with a thickness of (0.930 mm), (98.3%) drug content and 100% drug release within 6 mins and films pH was reassembled with the pH of saliva. <br /> International Journal Of Pharmacy 2249-1848 2013-10-01 4 716-721 Copyright (c) Pharma Scholars. All rights reserved 2013