Evaluation of Anti-Diarrheal and Central Nervous System Depressant Effect of Flacourtia indica in Swiss Albino Mice Md Al Foyjul Islam, A M Rakibur Rahman, Md Abdullah Al Sadi Khan, Arjyabrata Sarker, Md Jahir Alam, M S K Choudhuri, Runa Masuma* <p style="text-align: justify;"><em>Flacourtia indica</em> (FI) has been used in traditional system of medicines to treat several diseases like snakebite, cancer, diabetes and hepatic disorders. This study evaluated the anti-diarrheal and central nervous system (CNS) effect of ethanolic extract of FI in mice. Anti-diarrheal activity was evaluated using castor oil and MgSO<sub>4</sub> induced diarrhea tests in mice. GI motility was estimated using BaSO<sub>4</sub> milk. CNS effect was investigated using hole board, hole cross and elevated plus maze test. Extract was used at doses of 500 mg and 1000 mg/kg body weight. Loperamide (10 mg/kg p.o) and diazepam (4 mg/kg) were used as standard drug. The FI extract showed statistically significant anti-diarrheal effect in the total number of feces and episodes of diarrheal feces. Treatment with FI at both doses reduced diarrhea very highly significantly (p&lt;0.001) in castor oil and highly significantly (p&lt;0.01) in MgSO<sub>4</sub> induced diarrhea test. FI at 500 mg/kg and 1000 mg/kg doses caused a reduction in the diarrheal stools by 70% and 77.50% in castor oil induced diarrhea. In MgSO<sub>4</sub> induced diarrhea, the plant extract lowered diarrhea by 39.54% (p&lt;0.05) and 48.84% (p&lt;0.01) respectively. FI reduced GI motility very highly significantly (p&lt;0.001) at both the doses after 30 minutes of BaSO<sub>4</sub> administration. Standard drug loperamide (10 mg/kg) had very highly significant (p&lt;0.001) antidiarrheal effect. The extract resulted significant CNS depressant effect (p&lt;0.001) in hole board, hole cross and elevated plus maze test. The overall results depicted that the FI extract had significant antidiarrheal and CNS depressant properties.</p> International Journal Of Pharmacy 2249-1848 01-09-2018 4 28-37 Copyright (c) Pharma Scholars. All rights reserved 2013