Volume 9 - Issue 3

S.No Title & Authors Name Page
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Review Note International Journal of Pharmacy
Prachi K
 Abstract                  View                 Download                 XML

International Journal of Pharmacy commemorates its decade long service to the scientific community by consistently publishing peer-reviewed articles and tracking the progress and significant advancements in the field of pharmacy. Ever since its inception in the year 2010, in addition to regular issue releases on a quarterly basis, this transdisciplinary journal is also releasing special issues and conference proceedings from time to time, thus comprehensively covering a wide range of topics and emerging challenges in pharmacy. The journal focuses on application oriented research on pharmaceutical sciences, drug delivery systems, biochemical and biophysical principles with biotechnology, biomedical and biological relevance and utility. In this issue some of the recent and impactful research articles that were published by the journal will be discussed.

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Editor's note for International Journal of Pharmacy
Alice Evans
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I am pleased to introduce International Journal of Pharmacy (IJP) as the most highly rated peerreviewed research journal in pharmaceutical sciences category that publishes the latest research works relevant to pharmacy and other allied sciences. I am pleased to announce that during the year of 2020, till now all issues of volume 10 were published online well within schedule and the print issues were also brought out and dispatched within 30 days of publishing the issue online.

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Editorial Note : International Journal of Pharmacy
Alice Evans
 Abstract                  View                 Download                 XML

International Journal of Pharmacy commemorates its decade long service to the scientific community by consistently publishing peer-reviewed articles and tracking the progress and significant advancements in the field of pharmacy

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Editorial International Journal of Pharmacy
Emily Bennison
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Dear Readers,

On behalf of the Board of  the International Journal of Pharmacy (IJP) and my co-editors, I am glad to present the Volume 10, Issue 3 of  the journal. The journal established in 2010 has now published 10 Volumes; five issues in a year.

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HIGH LOCAL DELIVERY SYSTEMS OF ANTIBIOTICS IN THE TREATMENT OF BIOFILM RELATED INFECTIONS
Gerhard E. Maale, Aniruth Srinivasaraghavan, Daniel K. Mohammadi, Flavio A. Calderon II
 Abstract                  View                 Download                 XML

The use of local antibiotic delivery systems is common in the management of biofilm-related infections as they provide
high concentrations of local antibiotics while simultaneously avoiding complications from systemic toxicity. Older delivery
mechanisms were associated with a high incidence of wound complications (up to 25%) requiring reoperation. The high
wound complication rate was thought to be due to impurities from the mined calcium sulfate, hydrophobic behavior, and
acidic pH. We are presenting a 100% pure synthetic calcium sulfate hemihydrate (PSCSH) powder mixed with 240 mg liquid
tobramycin and 500 mg of vancomycin powder per 10 cc of the hemihydrate for use in revision surgeries for periprosthetic
joint infections (PJI). The purified carrier demonstrates superior utility to similar vehicles such as poly-methyl-methacrylate
(PMMA) due to the bioabsorbablity which takes 2-3 weeks as demonstrated by disappearance of the hydrated crystal on x-ray.
This is also preferable to the 4-6 weeks bioabsorbablity seen in the mined crystal calcium sulfate variants. The physiological
pH of the PSCSH and the hydrophilicity demonstrated in serum probably account for the low 4% wound complication rate.
The elution of vancomycin and tobramycin was greatest on day 1 compared with those concentrations obtained on days 2,
3, 4, and 5 post-operative while serum concentrations were mostly undetectable. Our findings demonstrate that this PSCSH
preparation provides therapeutic delivery of vancomycin and tobramycin locally at log 2-3 above the minimum inhibitory
concentration (MIC), while avoiding dangerous serum concentrations.

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