This study demonstrates the effect of three different super disintegrants, sodium starch glycolate (SSG), Polyplasdone XL and croscarmellose sodium (CCS) alone as well as in combination of SSG and Polyplasdone XL at different ratio (25:75, 50:50 & 75:25) and also without disintegrants. Direct compression technique was used to prepare Cetrizine hydrochloride tablets. Tablets were prepared with 2, 3 and 4% level of disintegrant and compared with tablets without disintegrant. Tablets were compressed at the breaking force range of 60-80 N. Compressed tablets were evaluated for weight, thickness, breaking force, friability, disintegration and dissolution. Formulation made without disintegrant shows very slow dissolution rate when compared to formulation with disintegrant. Formulations made with different disintegrants alone and also in combination show 90% drug release at 15 min time point versus 30 min in case of formulation without disintegrant. Formulation with 3 and 4% disintegrant level, SSG and Polyplasdone XL combination in different ratios shows significantly higher percentage drug release in initial time point when compared to the formulation containing SSG alone as disintegrant. The dissolution profile of formulations made with combination of disintegrants in 3 and 4% level was found to be in the order of SSG:PPXL (25:75) > SSG:PPXL (50:50) > SSG:PPXL (75:25). From the results of this study it can be concluded that SSG and Polyplasdone XL used in combination could be an alternative approach to increase the dissolution of the tablets when compared to the formulation with SSG alone as disintegrant.