Solanum ferox or Acid aubergine plants is one of the vegetables that are made in the food. Solanum ferox contains terpenoids compounds, steroids, flavonoids, alkaloids, and phenolic. Solanum ferox has antipyretic active compounds, antirheumatic, antiasthma, antiviral, and as a syphilis drug. The purpose of this research is the antibacterial activity of Solanum ferox plant leaf extract. Solanum ferox leaves are extracted using n-hexane and methanol. Both extracts were tested for antibacterial activity using diffusion method to use E. coli, S. aureus and B. subtilis bacteria. Amoxicillin is used as a positive standard whereas negative control is the solvent used to dissolve the sample. The antibacterial activity of n-hexane extract and amoxicillin showed inhibitory zone to E. coli of 7.80-12.93 mm and 19.97 mm, whereas in S. aureus and B. subtilis did not provide inhibition zone. Antibacterial activity of methanol extract against E. coli and amoxicillin were 7,72-11,67 mm and 19,97 inhibitory zone to bacterium B. subtilis only at 5.7 μg/mL concentration of 11, 29 mm and amoxicillin 18,51 mm.