A highly sensitive, accurate and rapid HPLC analytical method for the determination of Tenoxicam (TEN), Piroxicam (PIR) and Meloxicam (MEL) in a finished dosage form was developed and validated. C18 reversed phase column was used. The mobile phase was composed of methanol and aqueous buffer solution (disodium hydrogen phosphate dihydrate mixed with citric acid) (60:40),at pH of 5.8. The flow rate was 1.2 ml/min and the applied analytical wavelength was 360 nm. The calibration curve was linear over the range 1.010- 3.030, 1.513-4.538 and 1.765-5.295 mg/L for TEN, PIR and MEL, respectively. The lower limit of detection and the lower limit of quantification for TEN were 0.06 and 0.18 mg/L, while they were 0.09 and 0.28 mg/L, for PIR, and 0.12 and 0.38 mg/L, respectively for MEL. The peaks resolution was tested under several conditions and found that 5% increase of organic mixture or a 0.5 increase in the pH buffer would decrease the peak resolution between PIR and MEL. In conclusion, such method may successfully replace the classical analytical methods of Oxicams. <br />
This study was done to investigate the presence and the nature of treatment related problems in diabetic patients since it was not previously investigated. Two hundred patients were recruited in this cross sectional study. The end result is that the total number of treatment related problems was found to be 1518, with an average of 7.6 problems for each patient. The presence of actual treatment related problems as the most important determinant feature of diabetes control in out patients with diabetes. Besides four variables which were significantly associated with poor diabetes control (p= 0.05); which were: untreated condition, inappropriate adherence to medications, inappropriate adherence to clinic appointment and periodic laboratory tests, and efficacy treatment related problems.
It has been recently reported that the idea of cross-talks between hormone receptors including estrogen receptor (ER) and progesterone receptor (PR) in breast cancer to have significant impacts on breast cancer. The interactions of Epstein - Barr virus (EBV) and lymphoma have been previously demonstrated by many studies including ours. In this study, we aimed to examine the hypothesis that “EBV crosstalk with sex hormones plays a role in directing the type of lymphoma, Hodgkin’s Lymphoma (HL) or non –Hodgkin’s Lymphoma (NHL)”. We studied the expression of sex hormones, ER, and PR in addition to EBV in lymphoma cases representing HL and NHL. Immunoperoxidase staining was used to assess the expression of these biomarkers in lymphoma cases. The findings of our study showed that EBV cross talks with ER significantly associated with HL (p<0.05), while its talk with PR was significantly associated with NHL (p<0.05). Conclusions: The results of the present study showed that EBV may work as the maestro of an orchestra and leads the events of lymphoma through different crosstalk with sex hormones. This may open the door for new therapeutic options for lymphoma.
The purpose of this editorial is to show our experience in using both metformin and Urtica pilulifera (U. pilulifera) as diabetic therapeutic options. In brief, we would like to give some information about U. pilulifera and metformin.