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S.NO Title & Authors Name page
1
DEVELOPMENT OF A SIMPLE HPLC METHOD USING CORE-SHELL PARTICLES COLUMN FOR QUANTIFICATION OF IR3535 IN INSECT REPELLENT LIQUID FORMULATIONS.
Sinh Thai Nguyen, Jean-Paul Salvi, Elodie Gilbert, Celine Serre, Fabrice Pirot, Roselyne Boulieu
 Abstract                  View                 Download                 XML
A simple, fast, precise and sensitive method for the quantification of IR3535, an insect repellent used in topical formulations, was developed by reversed-phase high performance liquid chromatography. The separation was carried out by using a core-shell silica particles column (Kinetex  C18, 5??m, 4.6 mm x 150 mm) with a mobile phase consisting of 0.1% formic acid and methanol (40 : 60 v/v) in an isocratic mode at 0.5 ml/min and UV detection at 220 nm. The calibration curve was linear from 10 to 400 ??M, with regression coefficient r2 = 0.9999. Limit of detection (LOD) and Limit of quantification (LOQ) were found to be 1 and 10 ??M, respectively. Precision and accuracy fulfilled the acceptance criteria. This method was validated and may be routinely used for quantitative analysis of IR3535 from various topical insect repellent liquid formulations.
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2
DEVELOPMENT OF A HPLC METHOD FOR THE DETERMINATION OF ENROFLOXACIN AND CIPROFLOXACIN IN REPTILE PLASMA AFTER TRANSDERMAL DELIVERY
Iga Czyz, Jean-Paul Salvi, Alban Ducrotte, Plamen Kirilov, Sebastien Perrot, Charly Pignon, Fabrice Pirot, Francoise Falson, Roselyne Boulieu
 Abstract                  View                 Download                 XML
A rapid and simple high-performance liquid chromatography method using diode array detection for determination of enrofloxacin and ciprofloxacin in snake’s plasma was developed. Several snakes were treated transdermally with a single dose of enrofloxacin emulsions corresponding to an antibiotic dose of 5 mg/kg. Enrofloxacin and ciprofloxacin were analyzed using a core-shell silica particle stationary phase (Kinetex  RP–C18, 150 × 4.6 mm, particle size 5 µm) and 0.002 M phosphoric acid/acetonitrile (83:17, v/v) as mobile phase. Calibration curves were linear over the concentration range of 2–100 µM and 3–100 µM. The intra-day and inter-day coefficient of variations were below or equal to 10% for both compounds. Limits of quantification for enrofloxacin and ciprofloxacin were 2 µM and 3 µM respectively. Sample treatment procedure consisted of deproteinization with perchloric acid. The described HPLC method using core-shell silica particles results in better resolution, higher sensitivity and low back pressure.

571-576
3
NEW MATHEMATICAL MODEL BASED ON THE KINETIC PROFILE FOR THE PREDICTION OF MULTISTAGE DRUG RELEASE FROM DELIVERY SYSTEMS
Navideh Abbasnezhad, Farid Bakir, Mohammadali Shirinbayan, Blandine Maurel
 Abstract                  View                 Download                 XML

Because of a broad number of interdependent effects occurring during the release of drugs from controlled delivery systems, the associated phenomena become complex. Despite the availability of many researches to simulate these pharmacokinetics and dynamic aspects, the applicable models stay limited. In this work, we have developed an innovative mathematical model to predict the multistage-profiles of drug release. Thanks to the succession use of power functions reproducing the kinetic profile, the universal applicability of the proposed modeling becomes possible. This mathematical model makes it possible, in other words, to propose a behaviour law for the family of drug-carriers studied after experimental data adjustment of their release
profiles. The physical mechanisms are not directly modelled here, but they are contained in the modelled kinetics. In this way any group of physical mechanisms, coupled or not, are taken into account. To assess the development’s accuracy; we compare a published data set to predictions. The chosen examples here exploit distinct results about the effects of the coupled flow rate, drug-concentration, and the radius of the cylinder of the micro-needle patches. Predictions of this model are reachable from accessible design factors; we expect so users will select it to guide the formulations of a broad range of custom drug delivery system.

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