Country-wise Listing - Bosnia

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S.NO Title & Authors Name page
Semira Galijasevic, Elvisa Hodzic
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Lactoperoxidase (LPO) found in saliva, tears and airways protects system against bacterial and viral attack. It utilized hydrogen peroxide in the presence of halides or pseudohalide forming hypohalous acid a potent biocidal and virocidal agent. Melatonin is an important biomolecule that controls a number of functions including circadian sleep rhythms, blood pressure, oncogenesis, retinal function, seasonal reproduction, and immunity. Additionally, melatonin is frequently used as a supplement in a variety of medical conditions such as jet lag, shift work, and circadian rhythm sleep disorders, cancer, longevity and antioxidant therapy. Here, we demonstrate that melatonin modulates classic catalytic mechanism of LPO under physiological-like conditions. In the presence of chloride (SCN-), melatonin inactivated LPO classic peroxidase cycle by formation of compound II or two different intermediate compounds that are dead end products of LPO system. This behavior indicates that melatonin modulates the formation of LPO intermediates and their decay rates to the ground state this efficiently slowing down or inhibiting the cycling of the enzyme. Importantly, melatonin-dependent inhibition of LPO depends on hydrogen peroxide concentrations. Thus, the interplay between LPO and melatonin can have a broader implication especially in the cases of supplemental melatonin therapy.
Una Glamočlija, Sanin Haverić, Jasmina Čakar, Adaleta Durmić, Anja Haverić, Kasim Bajrović
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Despite the fact that Asplenium scolopendrium L. is a wide spread fern which has been used as a human remedy for centuries, there are very poor or no data about activity and genotoxicity of A. scolopendrium extracts. In this work, vacuum dried water and ethanol extracts of A. scolopendrium fronds were tested for their antimicrobial, cytotoxic and genotoxic potential. Antimicrobial activity was evaluated by disk diffusion assay (concentration of extracts 35 mg/ml, 7 mg/ml and 1,4 mg/ml) and there was no inhibition zone for all extracts and for all microorganisms examined (Escherichia coli, Staphylococcus aureus and Candida albicans). Cytotoxic and genotoxic potential of extracts (70 mg/ml, 7 mg/ml and 0,7 mg/ml) was tested using cytokinesis-block micronucleus cytome assay in human lymphocyte cultures. Ethanol blocked division of cells in negative control so only water extracts were analyzed. Extracts didn’t show genotoxic properties but they showed weak cytotoxic properties. NDI (nuclear division index) decreased with increasing concentration of extracts, but there was no statistical significance when compared to negative control (p=0,055).
Monoclonal Antibodies Handling and Administration Risk Management
Jaadar Y
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Background The use of Monoclonal Antibodies (MABs) has provided a new approach to treat various diseases and is in constant evolution. Hospital at home, new regulations and technologies are the next challenges for which healthcare professionals are confronted with. Therefore, risk assessment of MAB handling and administration must be considered. The aim of this study was to develop a tool providing recommendations regarding the MAB handling and administration. Method A review of the scientific literature was undertaken to identify MABs hazard characteristics, their immunogenic potential and their complexity of preparation. A tool was developed to classify MABs requiring a preparation in different groups providing specific handling and administration recommendations. Results An evaluation algorithm was developed to classify MABs regarding their toxicity and complexity of preparation. 28 MABs and 2 fusion proteins were assessed: 6 MABs presented a carcinogenic and/or mutagenic potential in animals. More than 65% of the MABs assessed exhibited teratogenic potential and 25% were highly or moderately immunogenic. 3 groups were defined providing specific recommendations for working staff. MAB side effects were also listed highlighting particular precautions for administration. Conclusion Most of the MABs assessed were not listed in known hazard drug lists (NIOSH, IARC). However, the literature reviewed has highlighted that some MABs exhibit carcinogenic or mutagenic properties in animal studies. Many of them are toxic for reproduction. Furthermore, sensitizing reaction and serious side effects can be observed. Despite their high molecular weight, MABs inhalation (ability to generate aerosol or powder handling) has been described as a potential route of occupational exposure. Studies on humans at low dose exposure should be conducted to allow the establishment of clear safety guidance for MABs handling and administration.