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Title Novel polymers for mucoadhesive drug delivery
Authors Abdul Malik, Nayyar Parvez, Pramod Kumar Sharma
Description The purpose of current article focuses on polymers used in mucoadhesive drug delivery system. The term “mucoadhesive” is defined as the “attachment of drug elongated with asuitable carrier like natural or synthetic polymer to mucus and/or an epithelial surface”. It is a popular novel drug delivery system because relatively permeable of mucous membranes, and mucus have higher blood flow therefore allowing rapidly uptake of a drug into the systemic circulation. It avoid the first pass metabolism. Mucoadhesive polymers are used in various dosage forms to obtained systemic delivery of therapeutics agent through the different mucosa. The dosage forms which involve in mucoadhesive drug delivery system are tablets, semisolids patches, powders, tapes and films. The mucoadhesive polymers which are used in various dosage form are PEG, Tragacanth, Guargum, HPMC, MC, sodiumCMC, CMC and Sodium alginate etc. and having mucoadhesive property. The ideal characteristics of a mucoadhesive polymer matrix is to adhere rapidly to the mucosal layer without founding any change in the physical property of the delivery matrix. The matrix have minimum interference to the release of the therapeutic agent and should be biodegradable without producing any toxic byproducts. The polymer matrix have a capability to inhibit the enzymes which is present at the delivery site and enhance the penetration of the therapeutics agent.The objective of this reviewarticle is to design improved drug delivery systems and to study about the novel mucoadhesive polymers used in mucoadhesive drug delivery system.