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|Title||FORMULATION AND EVALUATION OF ROSUVASTATIN NANOSUSPENSIONS|
|Authors||S Raja Shekhar and P Vijaya Lakshmi|
The objective of the present study was to formulate and evaluate nanosuspensions of rosuvastatin, a poorly soluble drug in order to enhance its solubility and dissolution chatacteristics. Rosuvastatin is a Biopharmaceutical Classification System (BCS) Class II drug having very low solubility therefore low oral bioavailability. In this study rosuvastatin nanosuspensions were prepared by precipitation technique followed by high frequency sonication by using a combination of stabilizers like PVP K90 and LUTROL F127 in different ratios. The formulated nanosuspensions were characterised by Scanning Electron Microscope (SEM) and FTIR. The formulations were evaluated for drug content, entrapment efficacy, Zetapotential and In-Vitro dissolution. SEM results showed the particle size of the formulated nanosuspensions in nanosize. FTIR spectrum revealed that there are no interactions between drug and carriers. The effect of particle size was found to be significant on the saturation solubility of the drug and in-vitro drug release studies showed significant increase in the dissolution rate of nanosuspensions as compared with pure drug.