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Title Effect of Ashwagandharista on Different Hepatic Enzymes at Three Different Dose Level Utilizing Male and Female Rat Model
Authors M. S. K. Choudhuri
Description Ashwagandharista (ASG) is a classical Ayurvedic preparation which is used as an anabolic. The key objective of this study was to analyze the effect of ASG on different enzyme profile i.e; Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline Phosphatase (ALP) and Lactate dehydrogenase (LDH). A total of 40 males and 40 females were randomly assigned to the four groups, namely group I (Control: water), group II (0.625 ml/kg BW of ASG), group III (5.0 ml/kg BW of ASG), and group IV (40.0 ml/kg BW of ASG) consisting of 10 males and 10 females in each group. To detect the outcome of ASG on different enzyme profile, it was administered chronically to both male and female Sprague-Dawley rats for 51 days. The results showed significant decrease of serum AST level in ASG treated male rat groups (p < 0.05) than control counterpart. In females, serum AST level in mid dose (group III) was significantly higher as compared to control (p < 0.05). The females from mid dose group showed significant increase in serum ALT level (p < 0.05) whereas other groups from male and female showed no significant changes. For the enzyme Lactate dehydrogenase, only the male rat high dose showed a significant decrease (p < 0.05) than the corresponding control group. No statistically significant change was noted in Alkaline Phosphatase level for both the male and female rats at three different doses.