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Title Chemoprofiling and Analgesic Effect of Methanol Leaves Extract and Fractions of Carica papaya
Authors *Omotoso Abayomi E and Igbinaduwa Patrick

The present study was carried out to identify the chemical compounds present in the partitioned extracts of C. papaya dried leaves using GC-MS technique and also to evaluate the analgesic activity of the methanol crude extract of the dried leaves obtained via hot method in mice using two laboratory models namely: hotplate latency assays and acetic acid induced writhing. The extract given orally (50-200 mg/Kg), increased the reaction time from 2.5 ± 0.6 to 5.3 ± 1.2 seconds in the hot plate model which showed a significant, dose dependent analgesic activity when compared with the control (p