Abstract

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Title ANTIOXIDANT ACTIVITY OF NEWLY SYNTHESISED IMIDAZOLE (2-(2-BENZYLIDENE HYDRAZINYL)-5, 5-DIPHENYL-1, 5-DIHYDRO-4H-IMIDAZOL 4-ONE)
Authors G. E. Suhasini, M. Nirmala, Varalakshmi, Archana Giri, B. Solomon G. Sahitha
Description The newly synthesized imidazole was evaluated for anti-oxidant activity. Chloro derivative of imidazole was synthesized. In three steps and has significant antidiabetic activity. Antioxidant activity is evaluated by estimating the free radical scavenging activity by DPPH method and nitric oxide method by. Invitro. whereas invivo antioxidant activity is evaluated by estimiating Enzyme catalase which catalyses hydrogen peroxide , lipid peroxidation by TBARS and reduced glutathione levels. Free scavenging activity of the cholro derivative increased with increasing dose. Catalase acitivity and glutathione reduction increased whereas lipid peroxidation decreased. The synthesized Chloro derivative has significant antioxidant activity.

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