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|Title||A REVIEW ON DRIED NANOSUSPENSIONS- A NOVEL FORMULATION TO ENHANCE SOLUBILITY OF POORLY AQUEOUS SOLUBLE DRUGS|
|Authors||S Raja Shekhar and P Vijaya Lakshmi|
Solubility is most important and crucial factor for drug effectiveness. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable. Nanosuspensions are one of the promising drug delivery systems proved to be very effective in eliminating the solubility problems and increasing the bioavailability of poorly soluble drugs. Nanosuspensions are very finely colloid, biphasic, dispersed, solid drug particles in an aqeous vehicle. These are prepared by using wet mill, high pressure homogenizer, emulsion-solvent evaporation, melt emulsification method and super critical fluid techniques. The most recent advancement in Nanosuspensions is Dried Nanosuspension which is prepared by freeze drying or spray drying of the formulated Nanosuspensions. It has higher stability and solubility properties than nanosuspensions. These can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels.